The study asked whether vitamin C or D supplementation improves mood state or reduces psychological distress in short-stay hospitalized patients based on the understanding that vitamin C & D deficiencies are common in acute-care hospitals and have been linked to mood disorders. A randomized, double-blind, active-control clinical trial compared the effects of vitamin C (500 mg twice daily) with those of high-dose vitamin D (5000 IU/d) on mood (Profile of Mood States) and psychological distress (Distress Thermometer).
Vitamin C was associated with a 71% reduction in mood disturbance and a 51% reduction in psychological distress suggesting that short-term therapy with vitamin C improves mood and reduces psychological distress in acutely hospitalized patients. Vitamin D supplementation had insignificant effects on mood and distress, however no conclusion is possible regarding the effects of vitamin D on mood or distress because the dose and duration of therapy were insufficient to raise blood plasma concentrations into the normal range.
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